Cubist Announces the Adoption of Notice and Access Rule for its 2008 Annual Meeting of Stockholders

Lexington, MA, May 1, 2008 -- Cubist Pharmaceuticals, Inc. (NASDAQ: CBST) today announced that it has elected to adopt the notice and access or "e-proxy" rules recently adopted by the Securities and Exchange Commission for its 2008 Annual Meeting of Stockholders. These rules allow Cubist to provide stockholders with access to proxy materials for the Annual Meeting via the Internet. Taking advantage of these new rules will allow Cubist to lower the cost of printing and mailing proxy materials to its stockholders and reduce the environmental impact of printing and mailing these materials.

Stockholders have been sent a notice by mail that details how to access the proxy materials and vote their shares via the Internet. The notice also provides stockholders with instructions on how to request hard copies of the proxy materials at no charge.

Cubist's Annual Meeting of Shareholders will be held on Wednesday, June 11, 2008 at 8:30 A.M. EDT at 55 Hayden Avenue, Lexington, MA.

About Cubist
Cubist Pharmaceuticals, Inc. is a biopharmaceutical company focused on the research, development, and commercialization of pharmaceutical products that address unmet medical needs in the acute care environment. In the U.S., Cubist markets CUBICIN® (daptomycin for injection), the first antibiotic in a new class of anti-infectives called lipopeptides. The Cubist product pipeline includes DX-88, a recombinant human protein in Phase II clinical trials for the prevention of blood loss during cardiothoracic surgery, and pre-clinical programs that address unmet medical needs in Gram-positive infections, Gram-negative infections, CDAD (Clostridium difficile-associated diarrhea), and HCV (Hepatitis C infections). Cubist is headquartered in Lexington, MA. Additional information can be found at Cubist's web site at www.cubist.com.